DE EN
  • Array

    News

Media release

HypoPet scientists publish data showing proof-of-principle achieved for a vaccine targeting osteoarthritic pain

Zürich Switzerland 19th of March 2019 – HypoPet AG today announced the publication of proof of principle data for a vaccine with the potential to translate into a novel therapy for osteoarthritic pain in companion animals. The data were published online 12th of March 2019 in an article entitled “Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis” in the Annals of the Rheumatic Diseases

A research collaboration between Martin Bachmann’s research groups at the Jenner Institute University of Oxford and University of Bern and academic researchers from the Kennedy Institute of Rheumatology University of Oxford and Latvian Biomedical Research and Study Center demonstrated the succesfull development and testing of a VLP-based vaccine with the potential to treat chronic pain caused by osteoarthritis. The virus-like particle vaccine triggers the immune system to produce antibodies that block the activity of nerve growth factor – a key mediator of inflammatory and chronic pain.

Professor Martin Bachmann CSO of HypoPet AG commented, “I am happy to see the vaccine platform perform so well, and look forward to seeing the vaccine enter clinical testing in companion animals in the near future”.

The Annals of the Rheumatic Diseases (ARD) is an international peer review journal committed to promoting the highest standards of scientific exchange and education. It covers all aspects of rheumatology, which includes the spectrum of musculoskeletal conditions, arthritic disease, and connective tissue disorders. ARD publishes basic, clinical, and translational scientific research. (https://ard.bmj.com/pages/about/?gclid=CjwKCAjw96fkBRA2EiwAKZjFTYm1MdJz6vmNZAGtS5Vjn2J54nbErLTptXKsfjkQz5ud6h36ZpCnwxoCn_gQAvD_BwE)


About pain and osteoarthritis
Effective and safe treatment of chronic pain associated with degenerative joint disease and cancer in companion animals is a major unmet need in veterinary medicine. The incidence of such diseases is increasing as companion animals age and live longer. As an example, mostly dogs but also cats and horses are affected by degenerative joint diseases. About 20% of dogs will develop osteoarthritis. The mainstays of current treatment are non-steroidal anti-inflammatory drugs, however, they are not sufficiently effective, have side effects and suffer convenience and compliance issues. Therefore, the need for new treatment options is significant. Experimental and clinical studies have identified a number of key molecules that mediate inflammatory and neuropathic pain and cancer pain. One of these molecules, nerve growth factor (NGF), is an ideal target for controlling pain using antibody based therapies. Indeed, in humans, dogs and cats, efficacy and safety have been demonstrated in with monoclonal antibodies that target NGF or its receptor.


References
Isabell S von Loga, Aadil El-Turabi, Luke Jostins, Jadwiga Miotla-Zarebska, Jennifer Mackay-Alderson, Andris Zeltins, Ida Parisi,1 Martin F Bachmann, Tonia L Vincent 2019 Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis. Ann Rheum Dis 2019 Mar 12. pii: annrheumdis-2018-214489. doi: 10.1136/annrheumdis-2018-214489. [Epub ahead of print]

Zeltins, A., J. West, F. Zabel, A. El Turabi, I. Balke, S. Haas, M. Maudrich, F. Storni, P. Engeroff, G.T. Jennings, A. Kotecha, D.I. Stuart, J. Foerster, and M.F. Bachmann. 2017. Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer's and cat allergy. NPJ Vaccines 2:30.5



For further information, please contact
Hypopet AG Moussonstrasse 2 CH-8044 Zürich
Gary Jennings, PhD
CEO
gary.jennings@hypopet.ch
Website www.hypopet.com


About HypoPet AG
HypoPet AG is a privately held Swiss biotechnology company based in Zürich, Switzerland that was formed as a spin-off company from the University of Zürich in 2013. HypoPet is developing therapeutic virus-like particle (VLP) vaccines (VLP) designed to instruct the patient’s immune system to produce antibodies which specifically neutralize disease-associated molecules within animal and thereby modulate chronic disease processes. Taking advantage of the flexibility of the platform VLP vaccine technology, HypoPet is establishing a high-quality pipeline filled with promising new animal drug candidates that address major unmet needs in veterinary medicine. The remarkable advances achieved in the treatment of chronic human diseases by the use of monoclonal antibodies can now be made available to our pets by the use of pet-specific vaccines. HypoPet is leveraging the experience of monoclonal antibodies, which have already achieved proof of principle (efficacy, safety & commercial) in humans and in some cases in companion animals.


Forward looking statement
This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Hypopet AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.

Go to the article
Download the press release

9th January 2019: HypoPet to present at Animal Health Investment Forum London
HypoPet AG today announced that it has been selected as a finalist to present at the prestigious Animal Health Investment Europe Forum in February 2019. The Animal Health Innovation showcase provides an opportunity for the most exciting and innovative emerging animal health companies, selected by committee, to present their breakthrough innovations and business to investors and industry professionals.

Company founder and CSO Martin Bachmann will give HypoPet’s 10 min presentation in London, Aldersgate on the 26th of February.

Proof of concept data for HypoPet’s virus-like particle vaccine for treating canine atopic dermatitis published in leading allergy journal.

Zürich Switzerland 11th of April 2018 – HypoPet AG today announced the publication of Proof of Concept data for a vaccine for treating canine atopic dermatitis (CAD) in the renowned Journal of Allergy and Clinical Immunology. The data were published online 4th of April 2018 in an article entitled “Vaccination against IL-31 for the treatment of atopic dermatitis in dogs”. Furthermore, the paper on canine atopic dermatitis is published “back to back” with a manuscript entitled “Treating insect bite hypersensitivity in horses with active vaccination against IL-5”. The vaccine described in this second work utilizes the same platform technology as that used by HypoPet.
Dr Gary T. Jennings CEO of HypoPet AG commented, “The encouraging result we achieved with the CAD vaccine (VC002) in a dog model of atopic dermatitis is a significant development milestone and suggests VC002 has the potential to make an important contribution to the treatment of this devastating condition. The tandem publications also show that our therapeutic virus-like particle vaccine platform is able to induce clinically effective levels of neutralizing antibodies against different targets and in different species. This ably demonstrates the potential of our technology to be developed in to effective veterinary medicines.”
The Journal of Allergy and Clinical Immunology publishes high-impact, cutting-edge clinical and translational research papers for allergists, immunologists, dermatologists, gastroenterologists, and other physicians and researchers interested in allergic diseases and clinical. The JACI is the most-cited journal in the field of allergy and clinical immunology.

About the CAD vaccine (VC002)
VC002 is a therapeutic vaccine in development for the treatment of canine atopic dermatitis (CAD). The product candidate VC002 represents a unique and novel approach to the treatment of CAD. Interleukin 31 is a key itch-inducing cytokine produced by immune cells in the skin during the allergic reaction in atopic dogs. The pruritic action of IL-31 can be neutralized with antibodies thereby providing marked clinical benefits to dogs suffering from CAD. VC002 is a virus-like particle nanoparticle vaccine designed to induce anti-IL31 antibodies when administered to dogs. In November 2015, Animal health company Benchmark Holdings PLC entered into an exclusive worldwide license agreement with Saiba Animal Health GmbH to develop and commercialize the CAD vaccine (since termed VC002). In May 2017, HypoPet AG merged with Saiba Animal Health and the CAD vaccine became part of HypoPet’s product pipeline.

About canine atopic dermatitis
Canine atopic dermatitis (CAD) is an allergic disease that affects up to 10 % of dogs. It stems from a genetic predisposition to develop allergic symptoms following exposure to substances that are usually harmless. Dogs afflicted with CAD develop itching, excessive scratching and rubbing, hair loss, greasy or flaky skin with a foul odor, excessive chewing on the paws, groin and armpits. Over time, the affected skin becomes raw, inflamed and infected. Treatment of the condition is life-long and until recently comprised allergen avoidance, symptomatic treatment, desensitization therapy and immunosuppressive therapies. These treatments had limited efficacy and were associated with side effects. Next generation biologic therapies, which includes HypoPet’s therapeutic vaccine, have the potential to provide better treatment options for CAD.

References
Zeltins, A., J. West, F. Zabel, A. El Turabi, I. Balke, S. Haas, M. Maudrich, F. Storni, P. Engeroff, G.T. Jennings, A. Kotecha, D.I. Stuart, J. Foerster, and M.F. Bachmann. 2017. Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer's and cat allergy. NPJ Vaccines 2:30.

Bachmann, M.F., A. Zeltins, G. Kalnins, I. Balke, N. Fischer, A. Rostaher, K. Tars, and C. Favrot. 2018. Vaccination against IL-31 for the treatment of atopic dermatitis in dogs. J Allergy Clin Immunol

Fettelschoss-Gabriel, A., V. Fettelschoss, F. Thoms, C. Giese, M. Daniel, F. Olomski, J. Kamarachev, K. Birkmann, M. Buhler, M. Kummer, A. Zeltins, E. Marti, T.M. Kundig, and M.F. Bachmann. 2018. Treating insect-bite hypersensitivity in horses with active vaccination against IL-5. J Allergy Clin Immunol


For further information, please contact
Hypopet AG Moussonstrasse 2 CH-8044 Zürich
Gary Jennings, PhD
CEO
gary.jennings@hypopet.ch
Website: www.hypopet.ch


About HypoPet AG
HypoPet AG is a privately held Swiss biotechnology company based in Zürich, Switzerland that was formed as a spin-off company from the University of Zürich in 2013. HypoPet is developing therapeutic virus-like particle (VLP) vaccines (VLP) designed to instruct the patient’s immune system to produce antibodies which specifically neutralize disease-associated molecules within animal and thereby modulate chronic disease processes. Taking advantage of the flexibility of the platform VLP vaccine technology, HypoPet is establishing a high-quality pipeline filled with promising new animal drug candidates that address major unmet needs in veterinary medicine. The remarkable advances achieved in the treatment of chronic human diseases by the use of monoclonal antibodies can now be made available to our pets by the use of pet-specific vaccines. HypoPet is leveraging the experience of monoclonal antibodies, which have already achieved proof of principle (efficacy, safety & commercial) in humans and in some cases in companion animals.


Forward looking statement
This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Hypopet AG. This publication may contain certain forward-looking statements and assessments or intentions concerning the company and its business. Such statements involve certain risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of the company to be materially different from those expressed or implied by such statements. Readers should therefore not place reliance on these statements, particularly not in connection with any contract or investment decision. The company disclaims any obligation to update these forward-looking statements, assessments or intentions.



Link to the research article in JACI
Download the media release here